2-hydroxy-6-pendadecylbenzoic acid, 6-(8(Z),11(Z),14-pentadecatrienyl)salicylic acid, 6-(8,11,14-pentadecatrienyl)salicylic acid, 6-nonadecyl salicylic acid, 6-pentadecyl salicylic acid, 6-pentadecylsalicylic acid, anacardic acid
| Name | Anacardic Acid | ||
| PubChem CID | 167551 | ||
| Molecular Weight | 348.5g/mol | ||
| Synonyms |
2-hydroxy-6-pendadecylbenzoic acid, 6-(8(Z),11(Z),14-pentadecatrienyl)salicylic acid, 6-(8,11,14-pentadecatrienyl)salicylic acid, 6-nonadecyl salicylic acid, 6-pentadecyl salicylic acid, 6-pentadecylsalicylic acid, anacardic acid |
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| Formula | C₂₂H₃₆O₃ | ||
| SMILES | CCCCCCCCCCCCCCCC1=C(C(=CC=C1)O)C(=O)O | ||
| InChI | 1S/C22H36O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h15,17-18,23H,2-14,16H2,1H3,(H,24,25) | ||
| InChIKey | ADFWQBGTDJIESE-UHFFFAOYSA-N | ||
| CAS Number | 11034-77-8 | ||
| ChEMBL ID | CHEMBL33778 | ||
| ChEBI ID | CHEBI:2696 | ||
| KEGG ID | C10759 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | BaiGuoYe | ||
| Use Part | Leaf | ||
| Habitat | China | ||
| Flavor | Bitter, Sweet, Astringent | ||
| Meridian Tropism | Heart, Lung, Spleen | ||
| Chineses Pinyin | DuXianZi | ||
| Use Part | Fruit | ||
| Habitat | FuJian, TaiWan, HaiNan, GuangXi, YunNan | ||
| Flavor | Sweet | ||
| Meridian Tropism | Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Sapindales
-->Family: Anacardiaceae
-->Genus: Anacardium
-->Species: Anacardium occidentale
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| Chineses Pinyin | YinXing | ||
| Habitat | ShenYang, GuangZhou, JiangSu, ZheJiang, AnHui, FuJian, JiangXi, ShanDong, ShangHai, GuiZhou, YunNan | ||
| Flavor | Sweet; Bitter; Astringent | ||
| Meridian Tropism | Heart; Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Ginkgoales
-->Family: Ginkgoaceae
-->Genus: Ginkgo
-->Species: Ginkgo biloba
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| Pair Name | Anacardic Acid, Fluorouracil | |||
| Partner Name | Fluorouracil | |||
| Disease Info | [ICD-11: 2C10] | Pancreatic cancer | Investigative | |
| Gene Regulation | Up-regulation | Expression | CHMP1A | hsa5119 |
| Up-regulation | Phosphorylation | TP53 | hsa7157 | |
| In Vitro Model | Capan-2 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_0026 |
| BxPC-3 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_0186 | |
| PANC-1 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_0480 | |
| Result | Our data suggests that Anacardic Acid might be a promising complementary supplement to slow the initiation or progression of pancreatic cancer. | |||
| Pair Name | Anacardic Acid, Bortezomib | |||
| Partner Name | Bortezomib | |||
| Disease Info | [ICD-11: 2A83] | Multiple myeloma | Investigative | |
| Biological Phenomena | Induction-->Endoplasmic reticulum stress | |||
| Gene Regulation | Up-regulation | Expression | ATF4 | hsa468 |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP8 | hsa841 | |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| Up-regulation | Expression | DDIT3 | hsa1649 | |
| Up-regulation | Phosphorylation | EIF2S1 | hsa1965 | |
| Up-regulation | Expression | HSPA4 | hsa3308 | |
| Up-regulation | Expression | HSPA5 | hsa3309 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| In Vitro Model | U266B1 | Plasma cell myeloma | Homo sapiens (Human) | CVCL_0566 |
| Result | The results of the present study suggest that AA/Bor combination may be a potential therapeutic strategy for MM treatment. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Anacardic acid inhibits pancreatic cancer cell growth, and potentiates chemotherapeutic effect by Chmp1A - ATM - p53 signaling pathway. BMC Complement Altern Med. 2018 Feb 20;18(1):71. doi: 10.1186/s12906-018-2139-3. | Click |
| 2 | Combined therapeutic effects of bortezomib and anacardic acid on multiple myeloma cells via activation of the endoplasmic reticulum stress response. Mol Med Rep. 2016 Sep;14(3):2679-84. doi: 10.3892/mmr.2016.5533. | Click |
